Stephen H Bryant and Stephen F Altschul
نویسندگان
چکیده
The past two years have seen the rapid development of new recognition methods for protein structure prediction. These algorithms ’thread’ the sequence of one protein through the known structure of another, looking for an alignment that corresponds to an energetically favorable model structure. Because they are based on energy calculation, rather than evolutionary distance, these methods extend the possibility of structure 1 of 17 12/3/97 4:27 PM Curr Opin Struct Biol http://biomednet.com/cgi-bin/fulltext/deliver.pl?uid=sb5210&picshow=fu
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MOTIVATION With the continuing rapid growth of protein sequence data, protein sequence comparison methods have become the most widely used tools of bioinformatics. Among these methods are those that use position-specific scoring matrices (PSSMs) to describe protein families. PSSMs can capture information about conserved patterns within families, which can be used to increase the sensitivity of ...
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Introduction Fast similarity search Similarity thresholds Refined structural alignments Concluding remarks Acknowledgements References and recommended reading Abbreviations Copyright
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